Molecular docking study of seventy-six phytomolecules from sixteen aromatics medicinal plants as promising inhibitors of five non-structural proteins of SARS-CoV-2

Since the identification of COVID-19 in China December 2019, scientists and researchers have been continuously discovering proposing drugs for this disease. Many efforts made to examine medicinal plants known their benefits treating infectious diseases actions boosting immune system. Repurposing FDA-approved antiviral has also advanced. However, no effective drug specific is currently available. To contribute search against disease, present study aims identify secondary metabolites (or phytomolecules) possessing an inhibitory effect on replication SARS-CoV-2, etiological agent COVID-19. 76 from 16 aromatics Madagascar were uploaded PubChem server. Then, they docked with 5 non-structural proteins (nsps) including main protease, papain-type RNA-dependent RNA polymerase, helicase 2'-O-methyltransferase, using Autodock Vina program integrated PYRIX 0.8 software. The results show that Cinnamosma fragrans (Capsicodendrin, Ugandensolide, Cinnamolide, Tocotrienol Pereniporin B) good affinity nsps SARS-CoV-2 can inhibit its functions viral replication. Therefore, these phytomolecules could be used development Nevertheless, further vitro vivo studies should performed valorize obtained by silico method.